Amlodipine besylate is a long-acting calcium channel blocker which has proved to be very potent in the curation of elevated blood pressure. It is a relatively new antihypertensive drug which is commonly prescribed as a single oral dose. Eleven (11) male wistar rats of 250g average body weight were used to determine the effect of Amlodipine besylate on the male reproductive hormones. Three dose levels (0.5, 1.0 and 10mg/kg) were used. The rats were all sacrificed on the eight day following treatment and the serum collected was sent for hormonal assay. The results obtained showed normal values of the reproductive hormones when compared with the control. This study strongly suggests that there was no significant reduction in the values of the reproductive hormones even at the highest dose administered. It could be said that Amlodipine besylate is good for the treatment of hypertension.
The Editor in Chief, Journal of Experimental Research Department of Anatomy, Enugu State University of Science and Technology, College Of Medicine (ESUCOM), GRA Enugu, Nigeria.
Enugu State University of Science and Technology